OBJECTIVE
To obtain a full-time industry position that would challenge my practical know-how in process design, experimental setup, data acquisition, mathematical modeling, and statistical analysis skills
EDUCATION
Ph.D. in Chemical Engineering Graduation date: Feb 12
GPA: 3.77/4.00
Florida State University, Tallahassee, FL
Thesis Title: Reaction-Diffusion Constraints Alter Spatial Organization of Mitochondria in Muscle fibers
Thesis Advisor: Prof. Bruce R. Locke, Department Chair, Chemical Engineering, Florida State University
Bachelor of Science in Chemical Engineering Graduation date: May 07
GPA: 3.70/4.00
National Institute of Technology (NIT), Jaipur, India
RESEARCH HIGHLIGHTS
Reaction Diffusion Modeling and Metabolic Optimization of Muscle System (Bioreactor) (Jan 08 – Feb 12):
Design and Optimization of Bioreactor -
• Developed a reaction-diffusion (RD) mathematical model in conjunction with on-line measurements of bioreactor unit for determination of nutrient (oxygen) consumption for muscle fiber survival
• Performed analysis of optimal nutrient flow rates for the bioreactor for different fiber types
Experiment & Model study for Structural Organization within the fiber –
• Obtained TEM images of different fiber types to determine their mitochondrial spatial distribution patterns
• Developed a two-dimensional (2-D) hybrid RD and cellular automata (CA) mathematical model to analyze the mitochondrial spatial organization
Mathematical Modeling techniques -
• Strang splitting method and alternate direction implicit (ADI) finite difference scheme is used in solving the 2-D RD model of the metabolites
• Developed a numerical algorithm using simulation software MATLAB for solving this hybrid RD-CA system
Model Results and Applications –
• Model Validation: Mitochondrial distribution data obtained from model was validated with the imaging data
• Obtained optimized distribution patterns of mitochondria with the fibers subjected to least diffusion constraints
• Statistical analysis of model data –Quantitative analysis of the shift in the mitochondrial distribution patterns for different conditions was performed using mean-weighted radii, weighted standard error techniques and the student’s t-test
• Applications –
- Determined redistribution patterns of mitochondria in fibers to prevent fiber from extreme hypoxia
- Determined mitochondrial volume density variation in endurance trained muscle for different fiber types
- Extended the mathematical model to develop a new mitochondrial rate law to account for Complex I mitochondrial malfunction in different fiber types
RELEVANT COURSES
Advanced Transport Phenomena, Advanced Chemical Engineering Mathematics, Advanced Chemical Engineering Thermodynamics, Advanced Reactor Design, Research Methods in Chemical Engineering, General Biochemistry I, General Biochemistry II, Special Topics in Biomedical engineering and Biomaterials, Design using finite element method, Advanced Polymer Science and Engineering
TEACHING EXPERIENCE
Teaching Assistant, Department of Chemical & Biomedical Engineering, Florida State University (40+ Students each)
• Transport Phenomenon &Unit Operations II Laboratory (Jan 08 – Apr 08)
- Supervised undergraduate engineering students in performing fluid flow and heat transfer experiments
- Acquainted the students with laboratory health and safety, experiment theories, data analysis, and operating procedures
• Process Control Laboratory (Apr 09 – Dec 09)
- Developed instruction modules for experiments. Conducted study sessions. Graded homework and quizzes
• Process Analysis and Design (Apr 10 – Dec 10)
- Assisted students in their assignments/projects involving numerical computation herein using MATLAB and COMSOL. Prepared homework solutions, graded homework and conducted office hours.
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